![]() The compounds were identified based on their elution order, retention times, spectra of the individual peaks (MS, MS/MS) additionally, by comparison with literature data. The quantitative results concerning selected iridoids, anthocyanins, phenolic acids, flavonols and hydrolyzable tannins of Cornelian cherry extracts used in this study are shown in Supplementary Materials Table S1 and Figure 1. The Chemical Composition of Cornelian Cherry Extracts extracts on the following two melanoma cell lines of different growth rates: A375 and MeWo.Ģ.1. This study aimed to explore the possible cytotoxic effect of two types (yellow and red) of C. extracts on melanoma cell lines could be found in the literature. inhibits the advanced glycation end-product-induced melanogenesis process in melanoma (B16 cell line) cells, no information on the cytotoxic effect of C. However, although some studies suggest that an extract from the fruits of C. extracts have been observed (based on the aforementioned studies) with the use of various tumor cell lines, such as the following: MCF-7, SKOV-3, PC-3, HeLa, HepG2, CaCo-2, HT29, CT26, A549. Cytotoxic/antiproliferative properties of C. compounds have been successfully applied in the form of nanoparticle carriers containing the extract itself or its various components. Furthermore, the antitumor and anti-inflammatory actions of C. Much attention has been drawn to the cytotoxic, antiproliferative, and thus, anti-cancer attributes of C. extracts (and fruit preserves ) may explain hepatoprotective, cardioprotective, nephroprotective, anti-atherosclerotic, antidiabetic, hypoglycemic and hypocholesterolemic effects of C. Moreover, anti-inflammatory and antioxidative properties of C. possess antibacterial and antifungal activity. According to the literature, extracts from C. Such interest in this species stems from the medical property of compounds (mainly-flavonoids, anthocyanins and iridoids) found in both the following: its leaves and fruits. ![]() The scientific database concerning one of the major representants of this family, the ‘Cornelian cherry’ ( Cornus mas L.), has reached over 4800 records. ĭue to their broad spectrum of utility, Cornaceae have long been discussed as a family of potential auxiliary uses in medicine, the food industry and cosmetics manufacturing. The introduction of phytochemicals as a potentially auxiliary factor in the antitumor treatment of melanoma is lately being discussed in the literature since many plant-derived compounds (in the following various forms: as plant extracts, single isolated compounds or compounds transported with nanocarriers) have yielded promising results against epithelial-mesenchymal transition, survival, invasion and metastatic capabilities of melanoma cells. This ability renders melanoma cells more resistant to targeted therapy and immunotherapy. The notoriety of melanoma stems from its high phenotype plasticity, which does not only increase the probability of the metastasis of this tumor (compared to other skin cancers) but also enables melanoma cells to rapidly adjust their transcriptional profile to the alterations within the tumor microenvironment, associated with the presence of various non-cancer cells and/or presence of different compounds, including drugs. Moreover, based on this study, there is no evidence for claiming a different magnitude of cytotoxicity between these two extracts. induced cytotoxicity in both A375 and MeWo cell lines, although the response of these cells was different. ![]() Cytotoxicity was assessed as a difference in the whole time series of cell viability, instead of analyzing differences in raw values (often found in the literature). An additional, alternative protocol for the SRB assay was used in this study so as to account for possible bias. Cytotoxicity was investigated with the use of the following two assays: SRB and MTT. The extracts were characterized in the context of the concentration of bioactive compounds of antioxidative properties. ‘Yantarnyi’ and ‘Flava’) Cornelian cherries on two melanoma cell lines (A375 and MeWo). This study aimed to explore the cytotoxic effect of extracts from fruits of red ( Cornus mas L. ![]() ![]() (Cornelian cherry), the extracts of which are reported to exert a pleiotropic effect shown in both in vivo and in vitro studies. Despite the fact that phytochemicals of Cornaceae species have long been discussed as possible auxiliary agents in contemporary treatment, the insights on their properties remain relatively scarce. ![]()
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